KINOX™:
Nitric oxide

Selective pulmonary vasodilator for the treatment of neonates.

or more information

KINOX™ is Air Liquide Healthcare's inhaled nitric oxide, specially developed as a selective pulmonary vasodilator for the treatment of neonates.

Medical application

KINOX™ is a selective pulmonary vasodilator developed by the Air Liquide Healthcare group and characterized by:

  • A rapid and reversible action1
  • A selective vasodilator which redistributes pulmonary blood flow1
  • Reduces the oxygenation index (OI) and increases PaO21
  • Absence of systemic effect2
  • Reduction in the shunt effect (V/Q) by acting only on ventilated
  • alveoli2

In persistent pulmonary hypertension of the newborn, inhaled nitric
oxide has been proven to:

  • Improve arterial oxygenation and shorten duration of mechanical ventilation and stay in ICU (Franco-Belgium collaborative NO Trial)3
  • Reduce the incidence of the initiation of extracorporeal membrane oxygenation (ECMO)4,5 without increasing the incidence of adverse outcomes at 1 year of age6
baby feet HC

KINOX™ is indicated, in conjunction with ventilator support and other appropriate agents, for the treatment of:

  • Newborn infants ≥ 34 weeks gestation with hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension, in order to improve oxygenation and to reduce the need for extracorporeal membrane oxygenation.
KINOX™ is available in 800 PPM concentration, in 2 cylinder sizes: 362 L cylinder (sz MD15) and 2138 L cylinder (sz NO88)

SoKINOX™ iNO delivery & monitoring device

SoKINOX™ is designed to bring easy-to-use inhaled nitric oxide  to the next level:

Universal: Functions with most ventilation modes, for all types of patients, thanks to its reliable flow sensor.

Intuitive and controlled: The large touchscreen provides clear and organized information, making the device intuitive and controlled through the alarms which are in place.

Compact: Its compact design includes a hand-bagging KINOX™ administration system in case of emergency, transfer, or alveolar recruitment.

Continuity: Connected to 2 cylinders with an automatic switch to guarantee treatment continuity.

Product information

Identification

Product form: Substance
Substance name: Nitric oxide
Formula: NO
Synonyms: Nitric oxide / Nitrogen oxide / Nitrogen monoxide / Nitrosyl radical / NO / iNO / Amidogen / Oxo / Kinox

Composition

Name Product identifier % Classification (GHS-CA)
Nitric Oxide (Compressed) (Main constituent (CAS No) 10102-43-9 > 99.9 Ox. Gas 1, H270 Press. Gas (Comp.), H280 Acute Tox. 1 (Inhalation:gas), H330 Skin Corr. 1B, H314 Eye Dam. 1, H318 STOT SE 2, H371

Safety information

Nitric oxide requires special care due to its oxidizing nature. Know the hazards and promote education for your patients and medical staff, to avoid safety hazards and create a safe work and living environment.

Safety data sheet (SDS)

Safe cylinder handling

References

  1. KINOX™ Product Monograph, Air Liquide Healthcare America Corporation, 2016
  2. Fumito Ichinose: A selective Pulmonary Vasodilator: Current uses and therapeutic potential. Circulation 2004:109:3106-3111.
  3. The Franco-Belgium Collaborative NO Trial Group. Early compared to delayed inhaled nitric oxide in moderately hypoxemic neonates with respiratory failure: a randomized controlled trial. Lancet 1999:354:1066-1071.
  4. The Neonatal inhaled Nitric Oxide Study Group. Inhaled nitric oxide in full-term and nearly full-term infants with hypoxic respiratory failure. N Eng J Med 1997: 336: 597-604.
  5. 5. Clark. R.H et al. Low dose nitric oxide therapy for persistent pulmonary hypertension of the newborn. NEJM volume 342, number 7.
  6. Clark. R.H et al. Low dose nitric oxide therapy for persistent pulmonary hypertension: 1 year followup. J Perinatol 2003:23:300-303.

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